Oral Vitamin B12 Replacement for the Treatment of Pernicious Anaemia

Many patients with pernicious anaemia are treated with lifelong intramuscular (IM) vitamin B12 replacement, the objective of this review is to provide an update on the effectiveness of oral vitamin B12 for the treatment of pernicious anaemia, the recommended dosage, and the required frequency of laboratory test and clinical monitoring. It concluded that oral vitamin B12 is an effective alternative to vitamin B12 IM injections. Patients should be offered this alternative after an informed discussion on the advantages and disadvantages of both treatment options.